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http://dx.doi.org/10.5012/bkcs.2012.33.1.111

Inhibitory Effect of 4-Aryl 2-Substituted Aniline-thiazole Analogs on Growth of Human Prostate Cancer LNCap Cells  

Baek, Seung-Hwa (Pharmacology Research Center, Bio-Organic Science Division, Korea Research Institute of Chemical Technology)
Kim, Nak-Jeong (Metabolic Syndrome Therapeutics Research Center, Bio-Organic Science Division, Korea Research Institute of Chemical Technology)
Kim, Seong-Hwan (Pharmacology Research Center, Bio-Organic Science Division, Korea Research Institute of Chemical Technology)
Park, Kwang-Hwa (Department of Pathology, Yonsei University Wonju College of Medicine)
Jeong, Kyung-Chae (Molecular Oncology Branch, National Cancer Center)
Park, Bae-Keun (Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine)
Kang, Nam-Sook (Graduate School of New Drug Discovery and Development, Chungnam National University)
Publication Information
Bulletin of the Korean Chemical Society / v.33, no.1, 2012 , pp. 111-114 More about this Journal
Abstract
Androgen receptor (AR) is ligand-inducible nuclear hormone receptor which has been focused on key molecular target in growth and progression of prostate cancer. We synthesized a series of 4-aryl 2-substituted aniline-thiazole analogs and evaluated their anti-cancer activity in AR-dependent human prostate cancer LNCap cells. Among them, the compound 6 inhibited the tumor growth in LNCap-inoculated xenograft model.
Keywords
Androgen receptor; Antagonist; LNCap cell; Prostate cancer;
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