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http://dx.doi.org/10.5012/bkcs.2012.33.10.3225

Synthesis and Physicochemical Characterization of Biodegradable PLGA-based Magnetic Nanoparticles Containing Amoxicilin  

Alimohammadi, Somayeh (Drug Applied Research Center, Tabriz University of Medical Sciences)
Salehi, Roya (Drug Applied Research Center, Tabriz University of Medical Sciences)
Amini, Niloofar (Faculty of Pharmacy, Tabriz University of Medical Sciences)
Davaran, Soodabeh (Faculty of Pharmacy, Tabriz University of Medical Sciences)
Publication Information
Bulletin of the Korean Chemical Society / v.33, no.10, 2012 , pp. 3225-3232 More about this Journal
Abstract
The purposes of this research were to synthesize amoxicillin-carrying magnetic nanoparticles. Magnetic nanoparticles were prepared by a chemical precipitation of ferric and ferrous chloride salts in the presence of a strong basic solution. PLGA and PLGA-PEG copolymers were prepared by ring opening polymerization of lactide (LA) and glycolide (GA) (mole ratio of LA: GA 3:1) with or without polyethylene glycol (PEG). Amoxicillin loaded magnetic PLGA and PLGA-PEG nanoparticles were prepared by an emulsion-evaporation process (o/w). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) photomicrographs showed that the magnetic nanoparticles have the mean diameter within the range of 65-260 nm also they were almost spherical in shape. Magnetic nanoparticles prepared with PLGA showed more efficient entrapment (90%) as compared with PLGA-PEG (48-52%) nanoparticles. In-vitro release of amoxicillin from magnetic PLGA nanoparticles showed that 78% of drug was released over 24 hours. The amount of amoxicillin released from PLGA-PEG s was higher than PLGA.
Keywords
Magnetic nanoparticles; PLGA; PLGA-PEG; Amoxicillin; Drug release;
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