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http://dx.doi.org/10.5012/bkcs.2011.32.8.2981

Photodynamic and Antioxidant Activities of Divalent Transition Metal Complexes of Methyl Pheophorbide-a  

Yoon, Il (PDT Research Institute, School of Nano System Engineering, Inje University)
Park, Ho-Sung (PDT Research Institute, School of Nano System Engineering, Inje University)
Cui, Bing Cun (PDT Research Institute, School of Nano System Engineering, Inje University)
Li, Jia Zhu (PDT Research Institute, School of Nano System Engineering, Inje University)
Kim, Jung-Hwa (PDT Research Institute, School of Nano System Engineering, Inje University)
Lkhagvadulam, Byambajav (PDT Research Institute, School of Nano System Engineering, Inje University)
Shim, Young-Key (PDT Research Institute, School of Nano System Engineering, Inje University)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.spc8, 2011 , pp. 2981-2987 More about this Journal
Abstract
A comparative study of the photodynamic and antioxidant activities of methyl pheophorbide-a (MPa, 1) and its transition metal(II) complexes (2-5) is described. Four transition metal complexes (palladium(II): 2, zinc(II): 3, cobalt(II): 4 and copper(II): 5) of MPa were prepared by reaction between the corresponding transition metal and 1, respectively, and were characterized by $^1H$-NMR and UV-vis spectroscopic and mass spectrometric analyses. In vitro results show a photodynamic therapy (PDT) efficacy with A549 cells might be attributed to a heavy atom effect of the transition metal complexes of MPa. Among them, 4 and 5 showed higher photodynamic activity than that of 1 at the concentration of 5 ${\mu}M$ at 24 h incubation after photoirradiation. The images of morphological change for 2-5 show evidence for the PDT effect with A549 cells. And the all transition metal complexes of MPa showed higher antioxidant activity than that of MPa, in which 4 showed the highest antioxidant activity.
Keywords
Antioxidant; In vitro study; Methyl pheophorbide-a; Photodynamic therapy; Transition metal(II) complex;
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