[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2011.32.8.2938

1,2,4-Triazinylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 Inhibitors

Kang, Suk-Youn (Research Center, Green Cross Corporation)
Kim, Min-Ju (Research Center, Green Cross Corporation)
Lee, Jin-Hwa (Research Center, Green Cross Corporation)

Publication Information

Bulletin of the Korean Chemical Society / v.32, no.spc8, 2011 , pp. 2938-2940 More about this Journal

Abstract

Novel C-aryl glucoside SGLT2 inhibitors containing triazine motif were designed and synthesized for biological evaluation. Among the compounds assayed, triazine containing methoxy moiety 18 demonstrated the best in vitro inhibitory activity against hSGLT2 in this series to date ( $IC_{50}$ = 24.9 nM).

Keywords

SGLT; Dapagliflozin; Triazine; Glucoside; Diabetes;

Citations & Related Records

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