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http://dx.doi.org/10.5012/bkcs.2011.32.8.2906

Spontaneous Nanoparticle Formation From a Fluorescent Nucleoside Analogue  

Bang, Eun-Kyoung (Department of Chemistry, Division of IBB, Pohang University of Science and Technology)
Moon, Do-Hyun (Beamline Division, Pohang Accelerator Laboratory, Pohang University of Science and Technology)
Kim, Byeang-Hyean (Department of Chemistry, Division of IBB, Pohang University of Science and Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.spc8, 2011 , pp. 2906-2910 More about this Journal
Abstract
A fluorescent nucleoside analogue, $^AC$, featuring two non-complementary nucleobases linked through an ethynyl group, was synthesized. The extended ${\pi}$-conjugation imparts $^AC$ with red-shifted absorbance (relative to adenine and cytosine) and pale-blue fluorescence. It spontaneously forms nanoparticles, which exhibit considerably enhanced fluorescence, without the help of any additional stabilizing agent. The DMSO/water ratio was an important factor influencing the construction of the NPs. X-ray crystallography confirmed the structure of $^AC$; dynamic light scattering and scanning electron microscopy confirmed the existence of the nanoparticles.
Keywords
Nucleosides; Hydrogen bonding; Self-assemblies; Nanoparticles;
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