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http://dx.doi.org/10.5012/bkcs.2011.32.8.2657

Synthesis of Triazoloquinoxalines as Antitubercular Agents  

Sekhar, Kondapalli Venkata Gowri Chandra (Chemistry Group, BITS, Pilani-Hyderabad Campus)
Rao, Vajja Sambasiva (Chemistry Group, BITS, Pilani-Hyderabad Campus)
Kumar, Dalip (Chemistry Group, BITS)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.8, 2011 , pp. 2657-2660 More about this Journal
Abstract
1,2,4-Triazoles and quinoxalines were found to display various pharmacological activities. Hence a series of 1-aryl-4-methyl-1,2,4-triazolo[4,3-a]quinoxalines were synthesized. Due to various advantages of organic reactions under solvent-free conditions these compounds were developed using iodobenzene diacetate under solvent-free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, $^1H$ NMR, $^{13}C$ NMR and HRMS. All the synthesized compounds were investigated for their antitubercular activity and 5g was found to the most active compound.
Keywords
Triazolo quinoxalines; Antitubercular; Iodobenzene diacetate;
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