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http://dx.doi.org/10.5012/bkcs.2011.32.7.2428

A Regiospecific One-Pot, Three Component Synthesis of 4-Aryl-6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones as New Potential Monoamine Oxidase Inhibitors  

Khalafy, Jabbar (Chemistry Department, Urmia University)
Rimaz, Mehdi (Chemistry Department, Urmia University)
Panahi, Leila (Chemistry Department, Urmia University)
Rabiei, Hossein (Chemistry Department, Urmia University)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.7, 2011 , pp. 2428-2432 More about this Journal
Abstract
A series of new 4-aryl-6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones have been synthesized via three component reaction of 1,3-dimethylbarbituric acid with arylglyoxals in the presence of hydrazinium dihydrochloride in ethanol. All of these derivatives may act as potential monoamine oxidase inhibitors.
Keywords
Pyrimido[4,5-c]pyridazine; Monoamine; Arylglyoxal; Barbituric acid;
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