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http://dx.doi.org/10.5012/bkcs.2011.32.3.947

DNA-Binding and Thermodynamic Parameters, Structure and Cytotoxicity of Newly Designed Platinum(II) and Palladium(II) Anti-Tumor Complexes  

Mansouri-Torshizi, Hassan (Department of Chemistry, University of Sistan and Baluchestan)
Saeidifar, Maryam (Department of Chemistry, University of Sistan and Baluchestan)
Khosravi, Fatemeh (Department of Chemistry, University of Sistan and Baluchestan)
Divsalar, Adeleh (Department of Biological Sciences Tarbiat Moallem University)
Saboury, Ali.Akbar (Institute of Biochemistry and Biophysics, University of Tehran)
Ghasemi, Zahra Yekke (Department of Chemistry, University of Sistan and Baluchestan)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.3, 2011 , pp. 947-955 More about this Journal
Abstract
The complexes [Pd(bpy)(Hex-dtc)]$NO_3$ and [Pt(bpy)(Hex-dtc)]$NO_3$ (bpy is 2,2'-bipyridine and Hex-dtc is hexyldithiocarbamato ligands) were synthesized and characterized by elemental analysis and spectroscopic studies. The cytotoxicity assay of the complexes has been performed on chronic myelogenous leukemia cell line, K562, at micromolar concentration. Both complexes showed cytotoxic activity far better than that of cisplatin under the same experimental conditions. The binding parameters of the complexes with calf thymus DNA (CT-DNA) was investigated using UV-visible and fluorescence techniques. They show the ability of cooperatively intercalating in CT-DNA. Gel filtration studies demonstrated that platinum complex could cleave the DNA. In the interaction studies between the Pd(II) and Pt(II) complexes with CT-DNA, several binding and thermodynamic parameters have been determined, which may provide deeper insights into the mechanism of action of these types of complexes with nucleic acids.
Keywords
DNA binding and thermodynamic parameters; Anti-tumor activity; Pd(II) and Pt(II) complexes;
Citations & Related Records
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Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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