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http://dx.doi.org/10.5012/bkcs.2011.32.1.71

Fast and Easy Drying Method for the Preparation of Activated [18F]Fluoride Using Polymer Cartridge  

Seo, Jai-Woong (Department of Chemistry, Inha University)
Lee, Byoung-Se (Research Institute of Labeling, FutureChem Co., Ltd.)
Lee, Sang-Ju (Department of Chemistry, Sogang University)
Oh, Seung-Jun (Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Chi, Dae-Yoon (Research Institute of Labeling, FutureChem Co., Ltd.)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.1, 2011 , pp. 71-76 More about this Journal
Abstract
An efficient nucleophilic [$^{18}F$]fluorination has been studied to reduce byproducts and preparation time. Instead of conventional aqueous solution of $K_2CO_3-K_{222}$, several organic solution containing inert organic salts were used to release [$^{18}F$]fluoride ion and anion bases captured in the polymer cartridge, concluding that methanol solution is the best choice. Comparing to azeotropic drying process, one min was sufficient to remove methanol completely, resulting in about 10% radioactivity saving by reducing drying time. The polymer cartridge, Chromafix$^{(R)}$ (PS-$HCO_3$) was pretreated with several anion bases to displace pre-loaded bicarbonate base. Phosphate bases showed better results than carbonate bases in terms of lower basicity. tert-Butanol solvent used as a reaction media played another critical role in nucleophilic [18F]fluorination by suppressing eliminated side product. Consequent [$^{18}F$]fluorination under the present condition afforded fast preparation of reaction solution and high radiochemical yields (98% radio-TLC, 84% RCY) with 94% of precursor remained.
Keywords
[$^{18}F$]Fluoride; Nucleophilic fluorination; Drying method; PET; Polymer cartridge;
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Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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1 Toorongian, S. A.; Mulholland, G. K.; Jewett, D. M.; Bachelor, M. A.; Kilbourn, M. R. Nucl. Med. Biol. 1990, 17, 273-279.
2 Jewett, D. M.; Toorongian, S. A.; Mulholland, G. K.; Watkins, G. L.; Kilbourn, M. R. Appl. Radiat. Isot. 1988, 39, 1109-1111.   DOI   ScienceOn
3 Ohsaki, K.; Endo, Y.; Yamazaki, S.; Tomoi, M.; Iwata, R. Appl. Radiat. Isot. 1998, 49, 373-378.   DOI   ScienceOn
4 Okarvi, S. M. Eur. J. Nucl. Med. 2001, 28, 929-938.   DOI   ScienceOn
5 Suehiro, M.; Vallabhajosula, S.; Goldsmith, S. J.; Ballon, D. J. Appl. Radiat. Isot. 2007, 65, 1350-1358.   DOI   ScienceOn
6 Coenen, H. H.; Klatte, B.; Knochel, A.; Schuller, M.; Stocklin, G. J. Labelled Compd. Radiopharm. 1986, 23, 455-466.   DOI   ScienceOn
7 Hamacher, K.; Coenen, H. H.; Stocklin, G. J. Nucl. Med. 1986, 27, 235-238.
8 Aerts, J.; Voccia, S.; Lemaire, C.; Giacomelli, F.; Goblet, D.; Thonon, D.; Plenevaux, A.; Warnock, G.; Luxen, A. Tetrahedron Lett. 2010, 51, 64-66.   DOI   ScienceOn
9 Lee, B. S.; Seo, J. W.; Lee, S. J.; Oh, S. J.; Chi, D. Y. J. Labelled Compd. Radiopharm. 2007, 50 (S1), S165.   DOI   ScienceOn
10 Lemaire, C. F.; Aerts, J. J.; Voccia, S.; Libert, L. C.; Mercier, F.; Goblet, D.; Plenevaux, A. R.; Luxen, A. J. Angew. Chem. Int. Ed. 2010, 49, 3161-3164.   DOI   ScienceOn
11 Moon, B. S.; Park, J. H.; Lee, H. J.; Kim, J. S.; Kil, H. S.; Lee, B. S.; Chi, D. Y.; Lee, B. C.; Kim, Y. K.; Kim, S. E. Appl. Radiat. Isot. 2010, 68, 2279-2284.   DOI   ScienceOn
12 Ametamey, S. M.; Honer, M.; Schubiger, P. A. Chem. Rev. 2008, 108, 1501-1516.   DOI   ScienceOn
13 Willmann, J. K.; van Bruggen, N.; Dinkelborg, L. M.; Gambhir, S. S. Nat. Rev. Drug Discovery 2008, 591-607.
14 Miller, P. W.; Long, N. J.; Vilar, R.; Gee, A. D. Angew. Chem. Int. Ed. 2008, 47, 8998-9033.   DOI   ScienceOn
15 Phelps, M. E. Proc. Natl. Acad. Sci. USA 2000, 97, 9226-9233.   DOI
16 Levin, C. S. Eur. J. Med. Mol. Imaging 2005, 32, S325-S345.   DOI
17 Kilbourn, M. R.; Hood, J. T.; Welch, M. J. Appl. Radiat. Isot. 1984, 35, 599-602.   DOI   ScienceOn
18 Kim, D. W.; Ahn, D.-S.; Oh, Y.-H.; Lee, S.; Kil, H. S.; Oh, S. J.; Lee, S. J.; Kim, J. S.; Ryu, J. S.; Moon, D. H.; Chi, D. Y. J. Am. Chem. Soc. 2006, 128, 16394-16397.   DOI   ScienceOn
19 Kim, D. W.; Song, C. E.; Chi, D. Y. J. Am. Chem. Soc. 2002, 124, 10278-10279.   DOI   ScienceOn
20 Jorapur, Y. R.; Chi, D. Y. Bull. Korean Chem. Soc. 2006, 27, 345-354.   DOI   ScienceOn
21 Lee, S. J.; Oh, S. J.; Chi, D. Y.; Kang, S. H.; Kil, H. S.; Kim, J. S.; Moon, D. H. Nucl. Med. Biol. 2007, 34, 345-351.   DOI   ScienceOn
22 Bergman, J.; Solin, O. Nucl. Med. Biol. 1997, 24, 677-683.   DOI   ScienceOn
23 Kim, D. W.; Jeong, H.-J.; Lim, S. T.; Sohn, M.-H. Angew. Chem. Int. Ed. 2008, 47, 8404-8406.   DOI   ScienceOn
24 Lee, C.-C.; Sui, G.; Elizarov, A.; Shu, C. J.; Shin, Y.-S.; Dooley, A. N.; Juang, J.; Daridon, A.; Wyatt, P.; Stout, D.; Kolb, H. C.; Witte, O. N.; Satyamurthy, N.; Heath, J. R.; Phelps, M. E.; Quake, S. R.; Tseng, H.-R. Science 2005, 310, 1793-1796.   DOI   ScienceOn
25 Gillies, J. M.; Prenant, C.; Chimon, G. N.; Smethurst, G. J.; Perrie, W.; Hamblett, I.; Dekker, B. A.; Zweit, J. Appl. Radiat. Isot. 2006, 64, 325-332.   DOI   ScienceOn
26 Nishijima, K.-I.; Kuge, Y.; Tsukamoto, E.; Seki, K.-I.; Ohkura, K.; Magata, Y.; Tanaka, A.; Nagatsu, K.; Tamaki, N. Appl. Radiat. Isot. 2002, 57, 43-49.   DOI   ScienceOn
27 Tilyou, S. M. J. Nucl. Med. 1991, 32, 15N-26N.