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http://dx.doi.org/10.5012/bkcs.2011.32.1.53

Differential Effects of Cysteine and Histidine-Capped ZnS:Mn Nanocrystals on Escherichia coli and Human Cells  

Kong, Hoon-Young (Department of Molecular Biology, Dankook University)
Kim, Song-Yi (Department of Chemistry, Dankook University)
Byun, Jong-Hoe (Department of Molecular Biology, Dankook University)
Hwang, Cheong-Soo (Department of Chemistry, Dankook University)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.1, 2011 , pp. 53-58 More about this Journal
Abstract
Cysteine and histidine-capped water-dispersible ZnS:Mn nanocrystals (ZnS:Mn-Cys and ZnS:Mn-His) were synthesized and their effects on E. coli and human cells were investigated. Particle sizes of these nanocrystals were found from HR-TEM images to be 3.5 nm and 4.0 nm, respectively. Their solution photoluminescence spectra showed identical broad emission peaks at 580 nm. ZnS:Mn-His significantly suppressed the growth of E. coli at $100{\mu}g/mL$ and 1 mg/mL concentrations, something not observed with ZnS:Mn-Cys. Consistent with this, greater inhibition of cell proliferation and viability were observed in HEK293 and IMR90 cells in ZnS:Mn-His at $100{\mu}g/mL$ and 1 mg/mL concentrations.
Keywords
ZnS:Mn nanocrystal; Amino acid capping; Cytotoxicity; E. coli; Human cells;
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