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http://dx.doi.org/10.5012/bkcs.2011.32.11.3899

Synthesis of Dendrimers from Alkyne-focal Dendrons by Oxidative Homo-coupling of Terminal Acetylene  

Han, Seung-Choul (Department of Medical Bioscience, Dong-A University)
Kim, Jong-Sik (Department of Chemistry, Dong-A University)
Lee, Jae-Wook (Department of Chemistry, Dong-A University)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.11, 2011 , pp. 3899-3903 More about this Journal
Abstract
General, fast, and efficient fusion methods for the synthesis of dendrimers with 1,3-diynes at a core were developed. The synthetic strategy was employed the oxidative homo-coupling of terminal alkyne. The oxidative homo-coupling reaction of the alkyne-functionalized Frechet-type dendrons 1-Dm was allowed to provide first through fourth generation dendrimers 2-Gm with 1,3-diynes at core. The fusion of the propargylfunctionalized PAMAM dendrons 3-Dm by homo-coupling of terminal alkyne lead to the formation of symmetric PAMAM dendrimers 4-Gm. Their structure of dendrimers was confirmed by $^1H$ and $^{13}C$ NMR spectroscopy, IR spectroscopy, mass spectrometry, and GPC analysis.
Keywords
Alkyne; Click chemistry; Dendrimer; Homo-coupling;
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