[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2010.31.8.2337

Synthesis, Anthelmintic and Anti-inflammatory Activities of Some Novel Imidazothiazole Sulfides and Sulfones

Shetty, Nitinkumar S. (Department of Chemistry, Changwon National University)
Khazi, Imtiyaz Ahmed M. (Department of Chemistry, Karnatak University)
Ahn, Chul-Jin (Department of Chemistry, Changwon National University)

Publication Information

Bulletin of the Korean Chemical Society / v.31, no.8, 2010 , pp. 2337-2340 More about this Journal

Abstract

A series of new 6-aryl-3-(3,4-dimethoxy-phenyl)-2-phenylsulfanyl-imidazo[2,1-b]-thiazole (5a-c) and 6-aryl-2-benzenesulfonyl-3-(3,4-dimethoxy-phenyl)imidazo[2,1-b]- thiazole (6a-c) have been prepared and characterized by analytical and spectral methods. The title compounds 5a-c and 6a-c were obtained by the reaction of 4-(3,4-dimethoxy-phenyl)-5-phenylsulfanyl-thiazol-2-ylamine (3) and 5-benzenesulfonyl-4-(3,4-dimethoxy -phenyl)thiazol-2-ylamine (4) with various phenacyl bromides in anhydrous ethanol. These newly synthesized compounds (5a-c and 6a-c) were screened for their anthelmintic and anti-inflammatory activities, where they have displayed better activities.

Keywords

Imidazo[2,1-b]thiazole; Sulfides; Sulfones; Anthelmintic activity; Anti-inflammatory activity;

Citations & Related Records

Times Cited By Web Of Science : 1 (Related Records In Web of Science)
Times Cited By SCOPUS : 2

Reference

1	Andreani, A.; Granaiola, M.; Leoni, A.; Locatelli, A.; Morigi, R.; Rambaldi, M.; Lenaz, G.; Fato, R.; Bergamini, C.; Farruggia, G. J. Med. Chem. 2005, 48, 3085. DOI
2	Andreani, A.; Granaiola, M.; Leoni, A.; Locatelli, A.; Morigi, R.; Rambaldi, M.; Garaliene, V.; Welsh, W.; Arora, S.; Farruggia, G. et al. J. Med. Chem. 2005, 48, 5604. DOI
3	Robert, J. F.; Boukraa, S.; Panouse, J. J.; Loppinet, V.; Chaumont, J. P. Eur. J. Med. Chem. 1990, 25, 731. DOI
4	Andreani, A.; Rambaldi, M.; Leoni, A.; Morigi, M.; Locatelli, A.; Georgi, G.; Lenaz, G.; Ghelli, A.; Esposti, M. D. Eur. J. Med. Chem. 1999, 34, 888.
5	Khazi, I. M.; Mahajanshetti, C. S.; Gadad, A. K. Arzneim Forsch. Drug Re. 1996, 46, 949.
6	Khazi, I. M.; Koti, R. S.; Chadha, M. V.; Mahajanshetti, C. S. Arzneim Forsch. Drug Re. 2005, 55, 107.
7	Shetty, N. S.; Koti, R. S.; Lamani, R. S.; Badiger, N. P.; Khazi, I. M. J. Sulf. Chem. 2008, 29, 539. DOI
8	Berlin, K. D.; Herd, M. D. Proc. Okla. Acad. Sci. 1991, 71, 29.
9	Kakarani, H. K.; Kalyani, G. A. Fitoterapia 1984, 55, 232.
10	Winter, C. A.; Risley, E. A.; Nuss, G. W. Proc. Soc. Exp. Biol. 1962, 111, 544. DOI
11	Thienopont, D. C.; Vanparijs, O. F. J.; Raeymaekers, A. H. M.; Vandenberk, J.; Demoen, P. J. A.; Allewijn, F. T. N.; Marsboom, R. P. H.; Niemegeers, C. J. E.; Shellekens, K. H. L.; Janssen, P. A. J. Nature 1966, 209, 1084. DOI

Reference

5	Hanan A. Mohamed. (2012) Journal of Sulfur Chemistry ]thiazoles / 33 (5) , 589
9	Juliano Alex Roehrs. (2012) Advanced Synthesis & Catalysis Three-Step One-Pot Synthesis of Imidazo[2,1-b]chalcogenazoles via Intramolecular Cyclization of N-Alkynylimidazoles / 354 (9) , 1791
8	Hazem A. Ghabbour. (2015) Medicinal Chemistry Research Synthesis, biological evaluation and molecular docking studies of thiazole-based pyrrolidinones and isoindolinediones as anticonvulsant agents / 24 (8) , 3194
1	(2010) Crystals [3+2] Cycloaddition Reaction for the Stereoselective Synthesis of a New Spirooxindole Compound Grafted Imidazo[2,1-b]thiazole Scaffold: Crystal Structure and Computational Study / 12 (1) , 5
7	Fang-Zhou Xu. (2017) Phosphorus, Sulfur, and Silicon and the Related Elements Synthesis and biological activity of novel sulfone derivatives containing a [1,2,4]triazolo[4,3-a]pyridine moiety / 192 (7) , 850
1	Nitinkumar S. Shetty. (2010) Chem Inform ChemInform Abstract: Synthesis, Anthelmintic and Antiinflammatory Activities of Some Novel Imidazothiazole Sulfides and Sulfones. / 42 (1) , None
None	(2020) Bioorganic chemistry Design and synthesis of novel Imidazo[2,1-<I>b</I>]thiazole derivatives as potent antiviral and antimycobacterial agents / 95 (None) , 103496
2	(2010) Journal of the Iranian Chemical Society Synthesis, crystal structure, antimicrobial activity and docking studies of new imidazothiazole derivatives / 17 (2) , 297
None	(2010) Journal of molecular structure Design, biological evaluation, molecular docking study and <I>in silico</I> ADME prediction of novel imidazo[2,1-<I>b</I>]thiazole derivatives as a novel class of α-glucosidase inhibitors / 1245 (None) , 131260