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http://dx.doi.org/10.5012/bkcs.2010.31.8.2265

Development of Worm-like Polymeric Drug Carriers with Multiple Ligands for Targeting Heterogeneous Breast Cancer Cells  

Lee, A-Hyeong (Division of Biotechnology, The Catholic University of Korea)
Oh, Kyung-Taek (College of Pharmacy, Chung-Ang University)
Baik, Hye-Jung (Division of Biotechnology, The Catholic University of Korea)
Lee, Bo-Reum (Division of Biotechnology, The Catholic University of Korea)
Oh, Young-Taik (Department of Diagnostic Radiology, Yonsei University College of Medicine)
Lee, Don-Haeng (Department of Internal Medicine, Inha University)
Lee, Eun-Seong (Division of Biotechnology, The Catholic University of Korea)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.8, 2010 , pp. 2265-2271 More about this Journal
Abstract
In this study, wormorm-like polymeric micelles were construted from poly(L-lactic acid)-b-poly(ethyelen glycol) (PLLA-b-PEG) block copolymers via worm-like (or cylindrical) self- assembly that consisted of a relatively long PLLA block ($M_n$ 7K Daltons) at the core and a relatively short PEG block ($M_n$ 2K Daltons) as the shell. Several cancer-targeting moieties (such as folate, cobalamin, and cyclic arginine-glycine-aspartic (RGD) peptide) were chemically coupled with the succinylated or maleimided PEG block of PLLA-b-PEG to act as a cancer cell-specific targeting ligand for breast cancer. The worm-like micelles with muplite cancer cell-specific ligands proved to be successful in recognizing different breast cancer cells at once. This has the potential to aid in cancer-specific drug delivery and to be used as an effective treatment for breast cancer.
Keywords
Worm-like micelle; Multiple ligands; Tumor targeting;
Citations & Related Records
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Times Cited By Web Of Science : 0  (Related Records In Web of Science)
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