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http://dx.doi.org/10.5012/bkcs.2010.31.8.2143

Facile Access to a Variety of 2,5-Biaryl-1,2,4-triazol-3-ones via Regioselective N-Arylation of Triazolones  

Park, Ji-Yeon (Department of Chemistry and Institute of Basic Sciences, Sungshin Women's University)
Chae, Jung-Hyun (Department of Chemistry and Institute of Basic Sciences, Sungshin Women's University)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.8, 2010 , pp. 2143-2146 More about this Journal
Abstract
A selective synthetic method of the 2,5-biaryltriazolones has been developed via copper-catalyzed N-arylation reaction. Aryltriazolones, which were readily prepared from commercially available compounds, were N-arylated to 2,5-biaryltriazolones with high regioselectivity. This approach allows for access to a variety of 2,5-biaryl-1,2,4-trizol-3-ones in a simple and practical manner.
Keywords
N-Arylation; Copper-catalyzed cross-coupling; N-Heterocycles; Regioselectivity; Triazolones;
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