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http://dx.doi.org/10.5012/bkcs.2010.31.7.1843

Azide/Alkyne Resins for Quick Preparation of 1,4-Disubstituted 1,2,3-Triazoles  

Sirion, Uthaiwan (Department of Chemistry, Inha University)
Lee, Jae-Hak (Department of Chemistry, Inha University)
Bae, Yu-Jin (Department of Chemistry, Inha University)
Kim, Hee-Jun (Department of Chemistry, Inha University)
Lee, Byoung-Se (Research Institute of Labeling, FutureChem Co., Ltd.)
Chi, Dae-Yoon (Research Institute of Labeling, FutureChem Co., Ltd.)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.7, 2010 , pp. 1843-1847 More about this Journal
Abstract
An efficient method for the preparation of 1,4-disubstituted 1,2,3-triazole compounds is described using polymeric quaternary ammonium salts having azide or alkyne functionality to remove unreacted excess starting molecules (azide/alkyne). Copper metal could easily be removed by simple filtration with a short $Na_2SO_4$/silica cartridge, affording highly regioselective products in high yield and excellent purity without the need for work-up, extraction and chromatographic purification.
Keywords
Click chemistry; Azide/alkyne resins; 1,2,3-Triazole; Huisgen 1,3-dipolar cycloaddition reaction;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
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