[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2010.31.5.1270

Synthesis of Benzoxazole Amides as Novel Antifungal Agents against Malassezia Furfur

Kim, Beom-Joon (Department of Dermatology, Chung-Ang University College of Medicine)
Kim, Jin-Ah (School of Pharmacy, Ewha Womans University)
Kim, Young-Kook (Immun Regulater Research Center, Korea Research Institute of Bioscience & Biotechnology(KRIBB))
Choi, Soon-Yong (Department of Biotechnology, College of Life Science & Nanotechnology, Hannam University)
ParkChoo, Hea-Young (School of Pharmacy, Ewha Womans University)

Publication Information

Bulletin of the Korean Chemical Society / v.31, no.5, 2010 , pp. 1270-1274 More about this Journal

Abstract

Malassezia is a pathogenic fungus that causes skin diseases, such as tinea versicolor, atopic dermatitis and fatal sepsis. We report the synthesis of a series of benzoxazole amides and evaluation of their antifungal activity against Malassezia furfur. Twelve benzoxazole amides were prepared through the cyclization of the substituted 2-hydroxy aniline with N-(bis-methylsulfanylmethylene) amides. Among the prepared compounds, the compounds 4a, 8b, 8c and 8d showed in vitro antifungal activity.

Keywords

Benzoxazole amides; Antifungal; Malassezia furfur;

Citations & Related Records

Times Cited By Web Of Science : 0 (Related Records In Web of Science)
Times Cited By SCOPUS : 1

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