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http://dx.doi.org/10.5012/bkcs.2010.31.5.1219

Solvent Free Microwave Accelerated Synthesis of Heterocyclic Thiazolidin-4-ones as Antimicrobial and Antifungal Agents  

Sekhar, Kondapalli Venkata Gowri Chandra (Chemistry Group, BITS, Pilani-Hyderabad Campus)
Rao, Vajja Sambasiva (Chemistry Group, BITS, Pilani-Hyderabad Campus)
Reddy, Aravalli Satish (Chemistry Group, BITS)
Sunandini, Ravada (Chemistry Group, BITS)
Satuluri, V S A Kumar (Chemistry Group, BITS)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.5, 2010 , pp. 1219-1222 More about this Journal
Abstract
A simple and efficient method has been developed for conversion of arenecarbaldehyde-3-methylquinoxalin-2-ylhydrazones to 3-(2-methylquinoxalin-3-yl)-2-(substitutedphenyl)thiazolidin-4-ones in good yields using microwave irradiation technique on silica as solid support under solvent free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, $^1H$ NMR, and mass spectroscopy. All the synthesized thiazolidinones were investigated for their antimicrobial and antifungal activities. The results of the biological activities revealed that the compounds 3b, 3d, 3f and 3h exhibited excellent antibacterial activities while 3d and 3h exhibited good antifungal activity.
Keywords
Quinoxalines; Silica; Microwave irradiation; Antibacterial; Antifungal;
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