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http://dx.doi.org/10.5012/bkcs.2010.31.5.1135

Synthesis, Spectral and Antimicrobial Studies of Some N(2)-Substituted Tetrahydroindazoles  

Amirthaganesan, Shanmugasundaram (Division of Image Science and Information Engineering, Pukyong National University)
Aridoss, Gopalakrishnan (Division of Image Science and Information Engineering, Pukyong National University)
Park, Keun-Soo (Division of Image Science and Information Engineering, Pukyong National University)
Lim, Kwon-Taek (Division of Image Science and Information Engineering, Pukyong National University)
Jeong, Yeon-Tae (Division of Image Science and Information Engineering, Pukyong National University)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.5, 2010 , pp. 1135-1142 More about this Journal
Abstract
A series of N(2)-benzothiazolyl substituted tetrahydroindazoles has been synthesized via cyclic ${\beta}$ keto esters. Optimum reaction condition was found as acidic toluene and effect of higher acidity towards substituted hydrazines in situ was described. Synthesized compounds have been achieved as single isomer and characterized by using 1D and 2D NMR spectral reports. Antimicrobial screening was carried out for the synthesized compounds along with a series of N(2)-pyridyl tetrahydroindazoles.1 The results of the in vitro antimicrobial screening studies revealed that compounds 13, 16 against Staphylococcus aureus, 11 against Escherichia coli, 10-12, 16 against Pseudomonas aeruginosa and 12 against Klebsiella pneumoniae recorded almost two-fold better activity compared to the standard drug used.
Keywords
Tetrahydroindazoles; Benzothiazolyl; 1(H) Indazoles; Antimicrobial activity;
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