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http://dx.doi.org/10.5012/bkcs.2010.31.04.929

Chemical Constituents from Acer mandshuricum and Their Effects on the Function of Osteoblastic MC3T3-E1 Cells  

Ding, Yan (College of Pharmacy, Chungnam National University)
Liang, Chun (College of Pharmacy, Chungnam National University)
Nguyen, Huu Tung (College of Pharmacy, Chungnam National University)
Choi, Eun-Mi (College of Pharmacy, Chungnam National University)
Kim, Jeong-Ah (College of Pharmacy, Chungnam National University)
Kim, Young-Ho (College of Pharmacy, Chungnam National University)
Publication Information
Abstract
A new compound, 4-methoxyl 5-hydroxymethyl benzoic 3-O-$\beta$-D-glucopyranoside (1), has been isolated from the leaves and stems of Acer mandshuricum, along with nine known compounds (2-10). Their structures were determined by a variety of spectroscopic analyses. The effect of compounds 1-10 on the function of osteoblastic MC3T3-E1 cells was examined by determining alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Compound 1 significantly increased the function of osteoblastic MC3T3-E1 cells; $5.0\;{\mu}M$ of 1 increased ALP activity, collagen synthesis, and mineralization of MC3T3-E1 cells to 114.7, 119.5, and 108.2% (P < 0.05) of the basal value, respectively. In addition, compounds 2-10 also potently increased the function of osteoblastic MC3T3-E1 cells.
Keywords
Acer mandshuricum; Aceraceae; 4-Methoxyl 5-hydroxymethyl benzoic 3-O-${\beta}$-D-glucopyranoside; Osteoblast differentiation; MC3T3-E1 cell;
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