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http://dx.doi.org/10.5012/bkcs.2010.31.04.863

A Convenient One-Pot Biginelli Reaction Catalyzed by Y(OAc)3: An Improved Protocol for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and Their Sulfur Analogues  

Aridoss, Gopalakrishnan (Division of Image Science and Information Engineering, Pukyong National University)
Jeong, Yeon-Tae (Division of Image Science and Information Engineering, Pukyong National University)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.4, 2010 , pp. 863-868 More about this Journal
Abstract
Yttrium(III) acetate hydrate-catalyzed novel synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one derivatives was achieved through one-pot three-component condensation of diversified aldehydes, $\beta$-ketoesters and urea or N-methylurea or thiourea with a molar ratio of 1:1:1.4. In comparison to the classical Biginelli approach, this catalytic method has the advantages of short reaction time and improved product yield.
Keywords
Biginelli reaction; 3,4-Dihydropyrimidin-2(1H)-one; Yttrium acetate;
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