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http://dx.doi.org/10.5012/bkcs.2010.31.03.664

New Synthetic Routes to Biologically Interesting Geranylated Acetophenones from Melicope Semecarpifolia and Their Unnatural Prenylated and Farnesylated Derivatives  

Xia, Likai (School of Chemical Engineering and Technology, Yeungnam University)
Narasimhulu, Manchala (School of Chemical Engineering and Technology, Yeungnam University)
Li, Xin (School of Chemical Engineering and Technology, Yeungnam University)
Shim, Jae-Jin (School of Chemical Engineering and Technology, Yeungnam University)
Lee, Yong-Rok (School of Chemical Engineering and Technology, Yeungnam University)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.3, 2010 , pp. 664-669 More about this Journal
Abstract
This paper describes a new synthetic approach for biologically interesting geranylated acetophenones. The first total syntheses of 1-(5-geranyloxy-7-hydroxy-2,2-dimethyl-2H-chromen-8-yl)ethanone and 1-[5-geranyloxy-7-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-2H-chromen-8-yl]ethanone, isolated from Melicope semecarpifolia, were carried out starting from commercially available 2,4,6-trihydroxyacetophenone.
Keywords
Geranylated acetophenone; Melicope semecarpifolia; Chalcone;
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