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http://dx.doi.org/10.5012/bkcs.2010.31.11.3353

Anti-Cancer Activity of T-Type Calcium Channel Blocker In Vivo  

Park, Hang-Ah (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University)
Jung, Soo-Yeon (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University)
Lee, So-Hyung (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University)
Kang, Han-Byul (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University)
Min, Min-Sik (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University)
Kim, Jung-Ahn (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University)
Choo, Dong-Joon (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University)
Oh, Chun-Rim (DongWoo Syntech Co., Ltd.)
Kim, Young-Deuk (DongWoo Syntech Co., Ltd.)
Lee, Kyung-Tae (Kyung Hee East-West Pharmaceutical Research Institute and Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University)
Lee, Jae-Yeol (Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.11, 2010 , pp. 3353-3358 More about this Journal
Abstract
3,4-Dihydroquinazoline 1 as T-type calcium channel blocker was in vivo evaluated against A549 xenograft in BALB/c-nu Slc mice, which exhibited 54% tumor growth inhibition through oral administration of 8 mg/kg of body weight and was slightly less active than doxorubicin (68%). In addition, this compound was also profiled for its acute toxicity to ICR mice to afford oral $LD_{50}$ value of 1,038 mg/kg of body weight.
Keywords
3,4-Dihydroquinazoline; Acute toxicity; A549 Xenograft; Anti-cancer;
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