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http://dx.doi.org/10.5012/bkcs.2010.31.11.3341

Synthesis, Crystal Structure and Fungicidal Activities of New Type Oxazolidinone-Based Strobilurin Analogues  

Li, Yuhao (Department of Applied Chemistry, College of Science, Nanjing University of Technology)
Liu, Rui (Department of Applied Chemistry, College of Science, Nanjing University of Technology)
Yan, Zhangwei (Department of Applied Chemistry, College of Science, Nanjing University of Technology)
Zhang, Xiangning (Jiangsu Pesticide Research Institute Co. Ltd.)
Zhu, Hongjun (Department of Applied Chemistry, College of Science, Nanjing University of Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.11, 2010 , pp. 3341-3347 More about this Journal
Abstract
A series of oxazolidinone-based strobilurin analogues were efficiently synthesized by the reaction of 3-(2-bromomethylphenyl) oxazolidin-2-one with 1-substituted phenyl-2H-pyrazolin-3-one. Their structures were confirmed and characterized by $^1H$-NMR, $^{13}C$-NMR, elemental analysis, and mass spectroscopy. In addition, the crystal structure of the target compound 3-(2-((1-phenyl-2H-pyrazol-3-yloxy)methyl)phenyl) oxazolidin-2-one was determined by single crystal X-ray diffraction. The bioassay results of these compounds indicated that some of the oxazolidin-2-one derivatives containing N-substituted phenyl 2H-pyrazol ring exhibited potential in vivo fungicidal activities against M. grisea at the dosage of $1\;g\;L^{-1}$.
Keywords
Strobilurin fungicide; Oxazolidinone; Synthesis; X-ray diffraction; Structure-activity relationships;
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