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http://dx.doi.org/10.5012/bkcs.2010.31.11.3309

Comparison of D-[18F]FMAU and L-[18F]FMAU as PET Imaging Agents for HSV1-TK Gene Expression  

Moon, Byung-Seok (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences)
Jo, Nam-Hyun (Biomaterials Center, Korea Institute of Science and Technology)
Lee, Kyo-Chul (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences)
El-Gamal, Mohammed I. (Biomaterials Center, Korea Institute of Science and Technology)
An, Gwang-Il (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences)
Hong, Su-Hee (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences)
Choi, Tae-Hyun (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences)
Choi, Won-Kyoung (Biomaterials Center, Korea Institute of Science and Technology)
Park, Jin-Hun (Biomaterials Center, Korea Institute of Science and Technology)
Cho, Jung-Hyuck (Biomaterials Center, Korea Institute of Science and Technology)
Cheon, Gi-Jeong (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences)
Oh, Chang-Hyun (Biomaterials Center, Korea Institute of Science and Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.11, 2010 , pp. 3309-3312 More about this Journal
Abstract
D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines. D-[$^{18}F$]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[$^{18}F$]FMAU. On the other hand, L-[$^{18}F$]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[$^{18}F$]FMAU. L-[$^{18}F$]FMAU can be utilized as a good candidate for HSV1-TK PET imaging. It can be used for antiviral drug evaluation.
Keywords
HSV1-TK; D-[$^{18}F$]FMAU; L-[$^{18}F$]FMAU; PET imaging; MicroPET;
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