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http://dx.doi.org/10.5012/bkcs.2009.30.9.2101

Synthesis of Facial Amphiphile 3,7-Diamino-5α-cholestane Derivatives as a Molecular Receptor  

Ahmad, Md. Wasi (Department of Applied Chemistry, Kyungpook National University)
Jung, Young-Mee (Department of Applied Chemistry, Kyungpook National University)
Khan, Sharaf Nawaz (Department of Applied Chemistry, Kyungpook National University)
Kim, Hong-Seok (Department of Applied Chemistry, Kyungpook National University)
Publication Information
Bulletin of the Korean Chemical Society / v.30, no.9, 2009 , pp. 2101-2106 More about this Journal
Abstract
A series of facial amphiphiles 3,7-diaminocholestane were synthesized from 3,7-diketocholestane via 2 sequential reductive aminations and anion recognition was evaluated with acetate, chloride, bromide, fluoride and phosphate anions. The stereo-selective reductive amination protocol was utilized to synthesized facial amphiphiles afforded receptors in high yields. The molecular receptor 2 showed the highest binding constant with acetate in a 1:1 ratio.
Keywords
Facial amphiphile; Anion receptor; Reductive amination; Aminosteroids; Stereoselectivity;
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