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http://dx.doi.org/10.5012/bkcs.2009.30.9.2066

Application of Cl3CCONH2/PPh3 towards the Synthesis of Bioactive Amides  

Chaysripongkul, Skydow (Department of Chemistry, Faculty of Science, Chulalongkorn University)
Pluempanupat, Wanchai (Department of Chemistry, Faculty of Science, Chulalongkorn University)
Jang, Doo-Ok (Department of Chemistry, Yonsei University)
Chavasiri, Warinthorn (Department of Chemistry, Faculty of Science, Chulalongkorn University)
Publication Information
Bulletin of the Korean Chemical Society / v.30, no.9, 2009 , pp. 2066-2070 More about this Journal
Abstract
$Cl_3CCONH_2$ coupled with $PPh_3$ was determined to be an effective reagent for the conversion of carboxylic acids to their corresponding acid chlorides. Subsequently, these acid chlorides were successfully trapped with amines in the presence of 4-picoline, yielding amides. This practical and efficient protocol can be utilized for the synthesis of biological amides in excellent yields.
Keywords
Trichloroacetamide; Triphenylphosphine; Chlorinating agent; Amide;
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