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http://dx.doi.org/10.5012/bkcs.2009.30.9.2027

Synthesis and Antiproliferative Activities of 1-Substituted-3-(3-chloro-5-methoxyphenyl)-4-pyridinylpyrazole Derivatives Against Melanoma Cell Line  

Choi, Won-Kyoung (Biomaterials Research Center, Korea Institute of Science and Technology)
Oh, Chang-Hyun (Biomaterials Research Center, Korea Institute of Science and Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.30, no.9, 2009 , pp. 2027-2031 More about this Journal
Abstract
The synthesis of a new series of diarylureas and amides having a 1-substituted-3-(3-chloro-5-methoxyphenyl)-4- pyridinylpyrazole scaffold is reported here. The in vitro antiproliferative activities of these diaryl derivatives against human melanoma cell line A375 were tested and the effect of substituents on the phenyl ring was investigated. Most of the newly synthesized compounds generally showed superior or similiar activity against A375 to Sorafenib. Among these compounds, IId, IIg and IIh showed excellent activity against A375 compared to Sorafenib.
Keywords
4-Pyridinylpyrazole; A375; Antiproliferative activity; Melanoma;
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1 Clark, J. W.; Eder, J. P.; Ryan, D.; Lathia, C.; Lenz, H. J. Clin. Cancer Res. 2005, 11, 5472   DOI   ScienceOn
2 Hirte, H. W.; Moore, M.; Siu, L.; Oza, A.; Hotte, S. J. Ann. Oncol. 2005, 16, 1688   DOI   ScienceOn
3 Strumberg, D.; Voliotis, D.; Moller, J. G.; Hilger, R. A.; Richly, H.; Kredtke, S. Int. J. Clin. Pharmacol. Ther. 2002, 40, 580   DOI
4 Richly, H.; Kupsh, P.; Passage, K.; Grubert, M.; Voigtmann, R.; Schwartz, B. Int. J. Clin. Pharmacol. Ther. 2004, 42, 650   DOI
5 Smith, R. A.; Barbosa, J.; Blum, C. L.; Bobko, M. A.; Caringal, Y. V.; Dally, R. Bioorg. Med. Chem. Lett. 2001, 11, 2775   DOI   ScienceOn
6 Wood, J. E.; Wild, H; Rogers, D. H.; Lyons, J.; Katz, M. E.; Caringal, Y. V. PCT Pat. Appl. WO 98052559, May 23, 1997
7 Bankston, D.; Dumas, J.; Natero, R.; Riedl, D. R.; Monahan, M.-K. Org. Proc. Res. Dev. 2002, 6, 777   DOI   ScienceOn
8 Khire, U. R.; Bankston, D.; Barbosa, J.; Brittelli, D. R.; Caringal, Y.; Carlson, R. Bioorg. Med. Chem. Lett. 2004, 14, 783   DOI   ScienceOn
9 Wan, P. T. C.; Garnett, M. J.; Roe, S. M.; Lee, S.; Niculescudunaz, D. Cell 2004, 116, 855   DOI   ScienceOn
10 Eisen, T.; Ahmad, T.; Flaherty, K. T.; Gore, M.; Kaye, S.; Marais, R.; Gibbens, I.; Hackett, S.; James, M.; Schuchter, L. M.; Nathanson, K. L.; Xia, C.; Simantov, R.; Schwartz, B.; Poulin-Costello, M.; O'Dwyer, P. J.; Ratain, M. J. Br. J. Cancer 2006, 95, 581   DOI   ScienceOn
11 Atallah, E.; Flaherty, L. Curr. Treat. Options Oncol. 2005, 6, 185   DOI   ScienceOn
12 Barth, A.; Wanek, L. A.; Morton, D. L. J. Am. Coll. Surg. 1995, 181, 193
13 Anderson, C. M.; Buzaid, A. C.; Legha, S. S. Oncol. (Williston Park) 1995, 9, 1149
14 Gray-Schopfer, V.; Wellbrock, C.; Marais, R. Nature 2007, 445, 851   DOI   ScienceOn
15 Garbe, C.; Eigentler, T. K. Melanoma Res. 2007, 17, 117   DOI   ScienceOn
16 Koon, H. B.; Atkins, M. B. Expert Rev. Anticancer Ther. 2007, 7, 79   DOI   ScienceOn
17 Wilhelm, S. M.; Carter, C.; Tang, L.; Wilkie, D.; Mcnabola, A.; Rong, H. Cancer Res. 2004, 64, 7099   DOI   ScienceOn
18 Strumberg, D.; Richly, H.; Hilger, R. A.; Schleucher, N.; Korfee, S. J. Clin. Oncol. 2005, 23, 965   DOI   ScienceOn