[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2009.30.6.1313

Discovery of Novel and Potent Cdc25 Phosphatase Inhibitors Based on the Structure-Based De Novo Design

Park, Hwang-Seo (Department of Bioscience and Biotechnology, Sejong University)
Jung, Suk-Kyeong (Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology)
Bahn, Young-Jae (Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology)
Jeong, Dae-Gwin (Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology)
Ryu, Seong-Eon (Department of Bio-engineering, Hanyang University)
Kim, Seung-Jun (Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology)

Publication Information

Bulletin of the Korean Chemical Society / v.30, no.6, 2009 , pp. 1313-1316 More about this Journal

Abstract

Cdc25 phosphatases have been considered as attractive drug targets for anticancer therapy due to the correlation of their overexpression with a wide variety of cancers. We have been able to identify five novel Cdc25 phosphatase inhibitors with micromolar activity by means of a structure-based de novo design method with a known inhibitor scaffold. Because the newly discovered inhibitors are structurally diverse and have desirable physicochemical properties as a drug candidate, they deserve further investigation as anticancer drugs. The differences in binding modes of the identified inhibitors in the active sites of Cdc25A and B are addressed in detail.

Keywords

Cdc25 phosphatase; De novo design; Inhibitor; Anticancer agents;

Citations & Related Records

Times Cited By KSCI : 2 (Citation Analysis)
Times Cited By Web Of Science : 1 (Related Records In Web of Science)
Times Cited By SCOPUS : 1

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