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http://dx.doi.org/10.5012/bkcs.2009.30.12.3025

Characterizations of Novel Poly(aspartic acid) Derivatives Conjugated with γ-Amino Butyric Acid (GABA) as the Bioactive Molecule  

Kim, Seung-Il (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University)
Son, Chang-Mo (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University)
Jeon, Young-Sil (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University)
Kim, Ji-Heung (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University)
Publication Information
Bulletin of the Korean Chemical Society / v.30, no.12, 2009 , pp. 3025-3030 More about this Journal
Abstract
Novel poly(aspartic acid) derivatives conjugated with $\gamma$-amino butyric acid, GABA, moieties, and their amphiphilic analogs were synthesized and characterized. The chemical structures of these polymers were confirmed by FT-IR and $^1H$ NMR spectroscopy. Their physicochemical properties in aqueous media were characterized by electrophonetic light scattering spectrophotometry (ELS), acid-base titration, and UV-spectroscopy. In addition, the in vitro cell activity of the GABA-conjugated polymer was examined. These results indicated that GABA-conjugated poly(aspartic acid) derivatives showed cell-growth activity and nanoparticle formation of a suitable size within aqueous media. These polymers have potential application in the cosmetic and pharmaceutical fields.
Keywords
Poly(aspartic acid); Bioconjugation; ${gamma}$-Amino butyric acid (GABA); Nanoparticle; Cell-growth activity;
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1 Kang, H. S.; Yang, S. R.; Kim, J. D.; Han, S. H.; Chang, I. S. Langmuir 2001, 17, 7501   DOI   ScienceOn
2 Goddard, J. M.; Hotchkiss, J. H. Prog. Polym. Sci. 2007, 32, 3698   DOI   ScienceOn
3 Min, S. K.; Kim, S. H.; Kim, J. H. Journal of Industrial Engineering Chemistry 2000, 6(4), 276
4 Giammona, G.; Pitarresi, G.; Tomarchio, V.; Spadaro, G. Colloid and Polymer Science, 1995, 273(6), 559   DOI
5 Nacato, T.; Yoshitake, M.; Matsubara, K.; Tomida, M.; Kakuchi, T. Macromolecules 1998, 31(7), 2107   DOI   ScienceOn
6 Wheeler, A. P.; Kosan, L. P. Mat. Res. Soc. Symp. Proc. 1993, 292, 279
7 Nakato, T.; Kusuno, A.; Kakuchi, A. J. Polym. Sci., Polym. Chem. 2000, 38(1), 117   DOI   ScienceOn
8 Masubara, K.; Nakato, T.; Tomida, M. Macromolecules. 1997, 30(8), 2305   DOI   ScienceOn
9 Kang, H. S.; Shin, M. S.; Kim, J. D.; Yang, J. W. Polymer Bulletin 2000, 45, 39   DOI   ScienceOn
10 Jiang, T. Y.; Wang, Z. Y.; Tang, L. X.; Mo, F. K.; Chen, C. Journal of Applied Polymer Science 2006, 99, 2702   DOI   ScienceOn
11 Jiang, T. Y.; Wang, Z. Y.; Chen, C.; Mo, F. K.; Xu, Y. L.; Tang, L. X.; Liang, J. J. Journal of Applied Polymer Science 2006, 101, 2871   DOI   ScienceOn
12 Horgan, A.; Saunderd, B.; Vincent, B.; Heenan, R. K. J. Colloid Interf. Sci. 2003, 262, 548   DOI   ScienceOn
13 Zhu, G. Eur. Polym. J. 2005, 41, 2671   DOI   ScienceOn
14 Matsusaki, M.; Hiwatari, K.; Higashi, M.; Kaneko, T.; Akashi, M. Chemistry Letters 2004, 33(4), 398   DOI   ScienceOn
15 Akagi, T.; Wang, X.; Uto, T.; Masanori, B.; Akashi, M. Biomaterials 2007, 28, 3427   DOI   ScienceOn
16 Filippov, S.; Hruby, M.; Konak, C.; Mackova, H.; Spirkova, M.; Stepanek, P. Langmuir 2008, 24, 9295   DOI   ScienceOn
17 Yang, S. R.; Lee, H. J.; Kim, J. D. Journal of Controlled Release 2006, 114, 60   DOI   ScienceOn
18 Li, P.; Yin, Y. L.; Li, D.; Kim, S. W.; Wu, G. British Journal of Nutrition 2007, 98, 237   DOI   ScienceOn
19 Belley, M.; Sullivan, R.; Reeves, A.; Evans, J.; O'Neill, G.; Gordon, Y. K. Bioorganic & Medicinal Chemistry 1999, 7, 2697   DOI   ScienceOn
20 Kim, S. I.; Min, S. K.; Kim, J.-H. Bull. Korean Chem. Soc. 2008, 29, 1887   과학기술학회마을   DOI   ScienceOn
21 Stella, B.; Arpicco, S.; Peracchia, M. T.; Desmaele, D.; Hoebeke, J.; Renoir, M.; Dangelo, J.; Cattel, L.; Couvreur, P. Journal of Pharmaceutical Sciences 2000, 89(11), 1452   DOI   ScienceOn
22 Stella, B.; Marsaud, V.; Arpicco, S.; Geraud, G.; Cattel, L.; Couvreur, P.; Renoir, J. M. Journal of Drug Targeting 2007, 15(2), 146   DOI   ScienceOn
23 Khandare, J.; Tamara, M. Prog. Polym. Sci. 2006, 31, 359   DOI   ScienceOn