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http://dx.doi.org/10.5012/bkcs.2009.30.12.3025

Characterizations of Novel Poly(aspartic acid) Derivatives Conjugated with γ-Amino Butyric Acid (GABA) as the Bioactive Molecule  

Kim, Seung-Il (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University)
Son, Chang-Mo (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University)
Jeon, Young-Sil (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University)
Kim, Ji-Heung (School of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University)
Publication Information
Bulletin of the Korean Chemical Society / v.30, no.12, 2009 , pp. 3025-3030 More about this Journal
Abstract
Novel poly(aspartic acid) derivatives conjugated with $\gamma$-amino butyric acid, GABA, moieties, and their amphiphilic analogs were synthesized and characterized. The chemical structures of these polymers were confirmed by FT-IR and $^1H$ NMR spectroscopy. Their physicochemical properties in aqueous media were characterized by electrophonetic light scattering spectrophotometry (ELS), acid-base titration, and UV-spectroscopy. In addition, the in vitro cell activity of the GABA-conjugated polymer was examined. These results indicated that GABA-conjugated poly(aspartic acid) derivatives showed cell-growth activity and nanoparticle formation of a suitable size within aqueous media. These polymers have potential application in the cosmetic and pharmaceutical fields.
Keywords
Poly(aspartic acid); Bioconjugation; ${gamma}$-Amino butyric acid (GABA); Nanoparticle; Cell-growth activity;
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