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http://dx.doi.org/10.5012/bkcs.2009.30.12.2959

Total Synthesis of Licochalcone E  

Yoon, Goo (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
Liu, Zhiguo (Korea Institute of Science and Technology, Gangneung Institute)
Jeong, Hee-Jin (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
Cheon, Seung-Hoon (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
Publication Information
Bulletin of the Korean Chemical Society / v.30, no.12, 2009 , pp. 2959-2961 More about this Journal
Abstract
Total synthesis of (${\pm}$)-licochalcone E (1), an allyl retrochalcone isolated from roots of Glycyrrhiza inflata, has been achieved from 4-tetrahydropyranyloxyacetophenone (7) with (E)-2-methoxy-4-(2-methyl-2-butenyloxy)benzaldehyde (6) or (Z)-2-methoxy-4-(2-methyl-2-butenyloxy)-benzaldehyde (11) through a convergent strategy involving aldol condensation and Claisen rearrangement as key steps.
Keywords
Licochalcone E; Aldol condensation; Claisen rearrangement; Synthesis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 6
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