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http://dx.doi.org/10.5012/bkcs.2008.29.8.1539

Poly(benzyl-L-histidine)-b-Poly(ethylene glycol) Micelle Engineered for Tumor Acidic pH-Targeting, in vitro Evaluation  

Lee, Eun-Seong (Division of Biotechnology, The Catholic University of Korea)
Youn, Yu-Seok (College of Pharmacy, Pusan National University)
Publication Information
Bulletin of the Korean Chemical Society / v.29, no.8, 2008 , pp. 1539-1544 More about this Journal
Abstract
A polymeric micelle, based on the poly(benzyl-L-histidine)-b-poly(ethylene glycol) (polyBz-His-b-PEG) diblock copolymer, was designed as a tumor-specific targeting carrier. The micelles (particle size: 67-80 nm, critical micelle concentration (CMC); 2-3 $\mu$g/mL) were formed from the diafilteration method at pH 7.4, as a result of self-assembly of the polyBz-His block at the core and PEG block on the shell. Removing benzyl (Bz) group from polyBz-His block provided pH-sensitivity of the micellar core; the micelles were physically destabilized in the pH range of pH 7.4-5.5, depending on the content of the His group free from Bz group. The ionization of His group at a slightly acidic pH promoted the deformation of the interior core. These pHdependent physical changes of the micelles provide the mechanism for pH-triggering anticancer drug (e.g., doxorubicin: DOX) release from the micelle in response to the tumor’s extracellular pH range (pH 7.2-6.5).
Keywords
Poly(benzyl-L-histidine); Acidic pH targeting; Triggering drug release
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