[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2008.29.8.1472

Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

Park, Hyeong-Beom (Biomaterials Research Center, Korea Institute of Science and Technology)
Jung, Myung-Ho (Biomaterials Research Center, Korea Institute of Science and Technology)
Cho, Jung-Hyuck (Biomaterials Research Center, Korea Institute of Science and Technology)
Oh, Chang-Hyun (Biomaterials Research Center, Korea Institute of Science and Technology)

Publication Information

Bulletin of the Korean Chemical Society / v.29, no.8, 2008 , pp. 1472-1478 More about this Journal

Abstract

The synthesis of a new series of 1 $\beta$ -methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5- azaspiro[2,4]heptane moiety showed the most potent antibacterial activity.

Keywords

1β -Methylcarbapenems; Antibacterial activity; Spiro[2,4]heptane; Substituent effects

Citations & Related Records

Times Cited By Web Of Science : 0 (Related Records In Web of Science)
Times Cited By SCOPUS : 0

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