Browse > Article
http://dx.doi.org/10.5012/bkcs.2008.29.10.1946

Synthesis and Biological Properties of New 5-Cyano-1,1-disubstituted Phthalans for the Treatment of Premature Ejaculation  

Kim, Dong-Sung (Research Laboratory, Dong-A Pharmaceutical Company)
Kang, Kyung-Koo (Research Laboratory, Dong-A Pharmaceutical Company)
Lee, Kyung-Seok (Research Laboratory, Dong-A Pharmaceutical Company)
Ahn, Byoung-Ok (Research Laboratory, Dong-A Pharmaceutical Company)
Yoo, Moo-Hi (Research Laboratory, Dong-A Pharmaceutical Company)
Yoon, Seung-Soo (Department of Chemistry, Sungkyunkwan University)
Publication Information
Bulletin of the Korean Chemical Society / v.29, no.10, 2008 , pp. 1946-1950 More about this Journal
Abstract
The synthesis of new 5-cyano-1,1-disubstituted phthalans having aromatic and aminoalkyl groups at C-1 position of phthalan ring and their biological evaluation are described. Most compounds exhibited comparable ejaculation-retarding effects to citalopram. Of these compounds, 3a, e showed excellent efficacy in delaying ejaculation.
Keywords
Premature ejaculation; Phthalans; Efficacy
Citations & Related Records

Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Yonezawa, A.; Watanabe, C.; Ando, R.; Furuta, S.; Sakurada, S.; Yoshimura, H.; Iwanagq, T.; Kimura, Y. Life Sciences 2000, 67, 3031   DOI   ScienceOn
2 Anon, N. Z. Drugs R&D. 2005, 6, 307   DOI   ScienceOn
3 Waldinger, M. D.; Hengeveld, M. W.; Zwinderman, A. H. Am. J. Psychiatry 1994, 151, 1377   DOI   ScienceOn
4 Waldinger, M. D.; Zwinderman, A. H.; Schweitzer, D. H.; Olivier, B. Int. J. Impot. Res. 2004, 16, 369   DOI   ScienceOn
5 Moreland, A. J.; Makela, E. H. Ann. Pharmacother. 2005, 39, 1296   DOI   ScienceOn
6 Goodman, R. E. J. Int. Med. Res. 1977, 5, 78
7 Rosen, R. C.; Lane, R. M.; Menza, M. J. Clin. Psychopharmacol. 1999, 19, 67   DOI   ScienceOn
8 Berkovitch, M.; Keresteci, A. G.; Koren, G. J. Urol. 1995, 154, 1360   DOI   ScienceOn
9 Xin, Z. C.; Choi, Y, D.; Lee, S. H. Yonsei Med. J. 1997, 38, 277
10 Biri, H.; Isen, K.; Sinik, Z.; Onaran, M.; Kupeli, B.; Bozkirli, I. Int. Urol. Nephrol. 1998, 30, 611   DOI   ScienceOn
11 Mendels, J.; Camera, A.; Sikes, C. J. Clin. Psychopharmacol. 1995, 15, 341   DOI   ScienceOn
12 Lee, H. S.; Song, D. H.; Kim, C. H.; Choi, H. K. J. Clin. Psychopharmacol. 1996, 16, 379   DOI   ScienceOn
13 Kim, S. C.; Seo, K. K. J. Urol. 1998, 159, 425   DOI   ScienceOn
14 Waldinger, M. D.; Hengeveld, M. W.; Zwinderman, A. H.; Olivier, B. J. Clin. Psychopharmacol. 1998, 18, 274   DOI   ScienceOn
15 Kara, H.; Aydin, S.; Yucel, M.; Agargum, M. Y.; Odabas, O.; Yilmaz, Y. J. Urol. 1996, 156, 1631
16 Waldinger, M. D.; Hengeveld, M. W.; Zwinderman, A. H. Br. J. Urol. 1997, 79, 592   DOI
17 McMahon, C. G.; Touma, K. J. Urol. 1999, 161, 1826   DOI   ScienceOn
18 Waldinger, M. D.; Zwinderman, A. H.; Olivier, B. J. Clin. Psychopharmacol. 2001, 21, 293   DOI   ScienceOn
19 Balbay, M. D.; Yildiz, M.; Salvarci, A.; Ozsar, O.; Ozbek, E. Int. Urol. Nephrol. 1998, 30, 81   DOI   ScienceOn
20 Fuller, R. W. Neurochem. Res. 1992, 17, 119
21 Giuliano, F.; Bernabe, J.; Gengo, P.; Alexandre, L.; Clement, P. J. Urol. 2007, 177, 386   DOI   ScienceOn
22 Bogeso, K. P.; Toft, A. S. U.S. Patent 4136193, 1979
23 de Jong, T. R.; Pattij, T.; Veening, J. G.; Dederen, P. J. W. C.; Waldinger, M. D.; Cools, A. R.; Olivier, B. Eur. J. Pharmacol. 2005, 509, 49   DOI   ScienceOn
24 Petersen, H.; Ahmadian, H.; Rock, M. H. U.S. Patent 6420574, 2002
25 Bogeso, K. P.; Perregaard, J. U.S. Patent 4943590, 1979
26 Safarinehad, M. R.; Hosseini, S. Y. Int. J. Impot. Res. 2005, 17, 1   DOI   ScienceOn
27 Atmaca, M.; Kuloglu, M.; Tezcan, E.; Semercioz, A. Br. J. Urol. Int. 2003, 91, 252   DOI   ScienceOn
28 Kim, S. W.; Paick, J. S. Urology 1999, 54, 544   DOI   ScienceOn
29 Waldinger, M. D.; Zwinderman, A. H.; Olivier, B. J. Clin. Psychopharmacol. 2001, 21, 556   DOI   ScienceOn
30 Andersson, K. E.; Mulhall, J. P.; Wyllie, M. G. Br. J. Urol. Int. 2006, 97, 311   DOI   ScienceOn
31 Atmaca, M.; Kuloglu, M.; Tezcan, E.; Semercioz, A. Int. J. Impot. Res. 2002, 14, 502   DOI   ScienceOn
32 Micheli, F.; Crippa, L.; Donati, D.; Fabio, R. D.; Leslie, C. Il Farmaco 2001, 56, 715   DOI   ScienceOn
33 Laumann, E. O.; Paik, A.; Rosen, R. C. JAMA. 1999, 281, 537   DOI   ScienceOn
34 Laumann, E. O.; Nicolosi, A.; Glasser, D. B. Int. J. Impot. Res. 2005, 17, 39   DOI   ScienceOn
35 Semans, J. H. South. Med. J. 1956, 49, 353   DOI   ScienceOn
36 Masters, W.; Johnson, V. Human Sexual Inadequacy; Little, Brown: Boston, Mass., 1970