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http://dx.doi.org/10.5012/bkcs.2007.28.8.1289

Isolation and Characterization of a New Alkaloid from the Seed of Prunus persica L. and Its Anti-inflammatory Activity  

Rho, Jung-Rae (Department of Marine Information Science, Wonkwang University)
Jun, Chang-Soo (Department of Bionanochemistry, Wonkwang University)
Ha, Young-Ae (Department of Bionanochemistry, Wonkwang University)
Yoo, Myung-Ja (Department of Bionanochemistry, Wonkwang University)
Cui, Ming-Xun (Department of Bionanochemistry, Wonkwang University)
Baek, Hwa-Seung (Professional Graduate School of Oriental Medicine, Wonkwang University)
Lim, Jin-A (Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Young-Haeng (Department of Bionanochemistry, Wonkwang University)
Chai, Kyu-Yun (Department of Bionanochemistry, Wonkwang University)
Publication Information
Bulletin of the Korean Chemical Society / v.28, no.8, 2007 , pp. 1289-1293 More about this Journal
Abstract
Persicaside has been isolated as a new alkaloid natural compound from a methanol (EtOA)-soluble extract of Prunus persica seed. It was purified by a combination of chromatographic techniques and recrystallization. The structure of Persicaside was determined by extensive NMR experiments and mass ppectroscopic data. It inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production via suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2 expression in rat osteoblast sarcoma cells (ROS 17/2.8) in concentration-dependent manner whereas it spares the COX-1 enzyme activity.
Keywords
Persicaside; Nitric oxide; Prostaglandin E2; Inducible nitric oxide synthase; Cyclooxygenase-2;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
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