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http://dx.doi.org/10.5012/bkcs.2007.28.7.1183

Determination and Temperature Dependence of n-Octanol/Water Partition Coefficients for Seven Sulfonamides from (298.15 to 333.15) K  

Congliang, Zhang (College of Chemical Engineering, Zhengzhou University)
Yan, Wang (College of Chemical Engineering, Zhengzhou University)
Fuan, Wang (College of Chemical Engineering, Zhengzhou University)
Publication Information
Bulletin of the Korean Chemical Society / v.28, no.7, 2007 , pp. 1183-1186 More about this Journal
Abstract
A shake-flask method was used to determine the n-octanol/water partition coefficients of sulfamethazine, sulfadimethoxine, sulfamethoxydiazine, sulfamonomethoxine, sulfamethoxazole, sulfaquinoxaline and sulfachloropyrazine from (298.15 to 333.15) K. The results showed that the n-octanol/water partition coefficient of each sulfonamide decreased with the increase of temperature. Based on the fluid phase equilibrium theory, the thermodynamic relationship of n-octanol/water partition coefficient depending on the temperature is proposed, and the changes of enthalpy, entropy, and the Gibbs free energy function for sulfonamides partitioning in n-octanol/ water are determined, respectively. Sulfonamides molecules partitioning in n-octanol/water is mainly an enthalpy driving process, during which the order degrees of system increased. The temperature effect coefficient of n-octanol/water partition coefficient is discussed. The results show that its magnitude is the same as that of values in the literature.
Keywords
Sulfonamide; n-Octanol/water partition coefficient; Temperature dependence;
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