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http://dx.doi.org/10.5012/bkcs.2007.28.6.990

Cytotoxic Polyketides from the Marine Sponge Discodermia calyx  

Shinde, Pramod B. (College of Pharmacy, Pusan National University)
Mansoor, Tayyab A. (College of Pharmacy, Pusan National University)
Luo, Xuan (College of Pharmacy, Pusan National University)
Hong, Jong-Ki (College of Pharmacy, Kyung Hee University)
Lee, Chong-O. (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology)
Jung, Jee-H. (College of Pharmacy, Pusan National University)
Publication Information
Bulletin of the Korean Chemical Society / v.28, no.6, 2007 , pp. 990-994 More about this Journal
Abstract
Bioassay-guided fractionation of the MeOH extract from the sponge Discodermia calyx collected off the coast of Jeju Island, South Korea, led to the isolation of a polyketide, icadamide C (1), along with previously reported theopederin K (3). Structure elucidation was performed by a combination of high resolution mass and 2D-NMR (principally COSY, HMBC, HSQC, and NOESY) spectroscopy. Stereochemistry of compound 1 was determined as 2R*, 3R*, 6R*, 10S*, 11S*, 12R*, 13S*, 15R* and 2'S by NMR data and Marfey analysis. Isolated metabolites displayed potent cytotoxic activity against a small panel of five human solid tumor cell lines with ED50 values of less than 0.1 μg/mL.
Keywords
Marine sponge; Discodermia calyx; Polyketide; Cytotoxicity; Marfey analysis;
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