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http://dx.doi.org/10.5012/bkcs.2007.28.5.777

A General Strategy for the Synthesis of Amino-Substituted 2-Pyridones Using a Palladium-Catalyzed Amination Reaction  

Kim, Young-Ha (Department of Chemistry, Chungnam National University)
Kim, Yeong-Joon (Department of Chemistry, Chungnam National University)
Chang, Sung-Youn (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology)
Kim, Bum-Tae (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology)
Heo, Jung-Nyoung (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.28, no.5, 2007 , pp. 777-782 More about this Journal
Abstract
A novel library of amino-substituted 2-pyridones has been constructed through a two-step sequence of microwave-promoted Buchwald-Hartwig amination of 2-benzyloxy halopyridines followed by debenzylation. Microwave-promoted amination of 3- or 4-halopyridine in the presence of a suitable palladium catalyst and ligand system provided amino-substituted 2-benzyloxypyridines in excellent yields. Then, debenzylation of 2- benzyloxypyridines afforded the corresponding 2-pyridones with high efficiency.
Keywords
2-Pyridone; Aminopyridine; Palladium-catalyzed amination; Microwave; Buchwald-Hartwig amination;
Citations & Related Records
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