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http://dx.doi.org/10.5012/bkcs.2007.28.2.225

New Cholinesterase Inhibitor, Lipoic Acid-Nitrone Derivatives  

Seo, Yun-Mi (Department of Biotechnology, Hanbat National University)
Nam, Kang-Hee (Department of Biotechnology, Hanbat National University)
Kang, Pill-Seong (COS Biotech, Inc.)
Ko, Sung-Bo (COS Biotech, Inc.)
Oh, Eu-Gene (COS Biotech, Inc.)
Sung, Min-Tae (Department of Biotechnology, Hanbat National University)
Choi, Byoung-Wook (Department of Biotechnology, Hanbat National University)
Lee, Bong-Ho (Department of Biotechnology, Hanbat National University)
Park, Jeong-Ho (Department of Biotechnology, Hanbat National University)
Publication Information
Bulletin of the Korean Chemical Society / v.28, no.2, 2007 , pp. 225-228 More about this Journal
Abstract
Lipoic acid (LA) is a multifunctional antioxidant against a variety of ROS. Nitrone acts as free radical spin trap and exhibits neuroprotective activity. Thus, LA-nitrone derivatives (6, 7, 8, and 9) were synthesized and screened as an antioxidant and inhibitors for cholinesterases. Even though the antioxidant effect of LA-nitrone derivatives was not improved, they turned out to be effective inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in μM range.
Keywords
Lipoic acid; Nitrone; Antioxidant; Cholinesterase inhibitor;
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