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http://dx.doi.org/10.5012/bkcs.2007.28.2.183

Determination of Buprenorphine in Raw Material and Pharmaceutical Products Using Ion-pair Formation  

Amanlou, Massoud (Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Medical Sciences/University of Tehran)
Khosravian, Peghah (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Azad University)
Souri, Effat (Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Medical Sciences/University of Tehran)
Dadrass, Orkideh Ghorban (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Azad University)
Dinarvand, Rasoul (Department of Pharmaceutics, Faculty of Pharmacy, Medical Sciences/University of Tehran)
Alimorad, Mohammad Massoud (Department of Pharmaceutics, Faculty of Pharmacy, Medical Sciences/University of Tehran)
Akbari, Hamid (Department of Pharmaceutics, Faculty of Pharmacy, Medical Sciences/University of Tehran)
Publication Information
Bulletin of the Korean Chemical Society / v.28, no.2, 2007 , pp. 183-187 More about this Journal
Abstract
A simple and sensitive extractive spectrophotometric method has been described for the determination of buprenorphine either in raw material or in pharmaceutical formulations. The developed method is based on the formation of a colored ion-pair complex (1 : 1 drug/dye) of buprenorphine and bromocresol green (BCG) in buffer pH 3 and extracting in chloroform. The extracted complex shows absorbance maxima at 415 nm. Beer's law is obeyed in the concentration range of 1.32-100.81 μ g mL-1. The proposed method has been applied successfully for the determination of drug in commercial sublingual tablets and injectable dosage form. No significant interference was observed from the excipients commonly used as pharmaceutical aids with the assay procedure.
Keywords
Spectrophotometry; Buprenorphine; Bromocresol green; Ion-pair complex;
Citations & Related Records

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