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http://dx.doi.org/10.5012/bkcs.2007.28.12.2338

Synthesis and Characterization of Some Quinazoline Derivatives as Potential Antimicrobial Agents under Microwave Irradiation  

Mehta, Sarika (Microwave Chemistry Laboratory, Department of Chemistry, University College of Science, ML Sukhadia University)
Swarnkar, Neelam (Microwave Chemistry Laboratory, Department of Chemistry, University College of Science, ML Sukhadia University)
Vyas, Madhuri (Microwave Chemistry Laboratory, Department of Chemistry, University College of Science, ML Sukhadia University)
Vardia, Jitendra (Microwave Chemistry Laboratory, Department of Chemistry, University College of Science, ML Sukhadia University)
Punjabi, Pinki B. (Microwave Chemistry Laboratory, Department of Chemistry, University College of Science, ML Sukhadia University)
Ameta, Suresh C. (Microwave Chemistry Laboratory, Department of Chemistry, University College of Science, ML Sukhadia University)
Publication Information
Bulletin of the Korean Chemical Society / v.28, no.12, 2007 , pp. 2338-2343 More about this Journal
Abstract
Under the framework of green chemistry, an efficient and extremely fast procedure for the synthesis of 5a-h through four-step procedure starting from 2-arylidenetetralin-1-one 1a-d under microwave irradiation is described. A considerable increase in the reaction rate has been observed with better yield. The structures of the synthesized compounds have been characterized on the basis of their elemental analysis and spectral data. Synthesized compounds 5a-h was evaluated for their antimicrobial activity. Some of the compounds exhibited appreciable activity.
Keywords
Tetralone; Chalcone; Thiazolidinone; Isoxalzoline; Microwave irradiation;
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