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http://dx.doi.org/10.5012/bkcs.2006.27.9.1397

Complexation between Venlafaxine Hydrochloride and β -Cyclodextrin:Structural Study by Nuclear Magnetic Resonance Spectroscopy  

Ali, Syed Mashhood (Department of Chemistry, Aligarh Muslim University)
Koketsu, Mamoru (Department of Chemistry, Aligarh Muslim University)
Asmat, Fahmeena (Division of Instrument Analysis, Life Science Research Center, Gifu University)
Publication Information
Bulletin of the Korean Chemical Society / v.27, no.9, 2006 , pp. 1397-1400 More about this Journal
Abstract
A detailed spectroscopic study ($^1H$ NMR, COSY, ROESY) of complexation of venlafaxine hydrochloride (VEN) with $\beta$-cyclodextrin ($\beta$--CD) was carried out in solution. The stoichiometry of the complex was determined to be 1 : 1 and penetration of aromatic ring into $\beta$-Cyclodextrin cavity was confirmed from primary rim side, with the help of ROESY spectral data. The structure of the venlafaxine hydrochloride-$\beta$-CD complex has been proposed. The association constant was determined to be 234 $M^{-1}$.
Keywords
$\beta$-Cyclodextrin; Venlafaxine hydrochloride; Inclusion complexes; $^1H$ NMR titration; ROESY;
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