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http://dx.doi.org/10.5012/bkcs.2006.27.9.1359

Synthesis of New Anthracycline Derivatives Containing Lactic or Stearic Acid Moiety  

Rho, Young S. (Department of Chemistry, Chonbuk National University)
Kim, Wan-Joong (Department of Chemistry, Chonbuk National University)
Yoo, Dong-Jin (Department of Chemistry, Seonam University)
Publication Information
Bulletin of the Korean Chemical Society / v.27, no.9, 2006 , pp. 1359-1363 More about this Journal
Abstract
Novel anthracycline analogues 2-9 as potential anticancer agents were synthesized from daunomycin (1a) and doxorubicin (1b). Compounds 2, 6, and 7 were prepared by the nucleophilic displacement type esterification of a 14-bromodaunomycin (1c) with a sodium lactate, and stearic acid, respectively. Compounds 3-5 and 7-9 were prepared by the reaction of either daunomycin (1a) or doxorubicin (1b) with L-lactic and stearic acids in the presence of EDCI/PP reagents.
Keywords
Daunomycin; Doxorubicin; Anthracycline derivatives; Lactic acid; Stearic acid;
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