[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2006.27.8.1164

Synthesis and Antibacterial Activity of 1β-Methyl-2-[5-(α,β-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem Derivatives. Part II

Kim, Jin-Woong (Medicinal Chemistry Research Center, Korea Institute of Science and Technology)
Park, Hyeong Beom (Medicinal Chemistry Research Center, Korea Institute of Science and Technology)
Chung, Bong Young (Department of Chemistry, Korea University)
Lee, Jong Baek (Department of Chemical Engineering, Dongeui University)
Cho, Jung-Hyuck (Medicinal Chemistry Research Center, Korea Institute of Science and Technology)
Oh, Chang-Hyun (Medicinal Chemistry Research Center, Korea Institute of Science and Technology)

Publication Information

Bulletin of the Korean Chemical Society / v.27, no.8, 2006 , pp. 1164-1170 More about this Journal

Abstract

The synthesis of a new series of 1 $\beta$ -methylcarbapenems having 5-( $\alpha,\beta$ -disubstituted ethyl)pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (VIh) having $\alpha$ -hydroxy- $\beta$ -piperazinylethyl substituted moiety showed the most potent activity.

Keywords

1 $\beta$ -Methylcarbapenem; Antibacterial activity; DHP-I stability;

Citations & Related Records

Times Cited By Web Of Science : 1 (Related Records In Web of Science)
Times Cited By SCOPUS : 1

Reference
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