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http://dx.doi.org/10.5012/bkcs.2006.27.6.857

Asymmetric Michael Reaction of Malonate Derivatives with α, β-Unsaturated Ketones  

Cho, Min-Je (Department of Chemistry, Soonchunhyang University)
Cho, Myoung-Gi (Department of Chemistry, Soonchunhyang University)
Huh, Sun-Chul (Department of Chemistry, Soonchunhyang University)
Kim, Sung-Min (Department of Chemistry, Soonchunhyang University)
Lee, Kil-sung (Cheil Indusries Inc.)
Koh, Kwang-Oh (Department of Chemistry, Soonchunhyang University)
Mang, Joo-Yang (Department of Chemistry, Soonchunhyang University)
Kim, Dae-Young (Department of Chemistry, Soonchunhyang University)
Publication Information
Bulletin of the Korean Chemical Society / v.27, no.6, 2006 , pp. 857-862 More about this Journal
Abstract
The catalytic enantioselective Michael reaction promoted by quaternary ammonium salts from Cinchona alkaloids as a phase-transfer catalyst is described. Treatment of malonates with $\alpha$,$\beta$-unsaturated ketones under mild reaction conditions afforded the corresponding Michael adducts in good yields with good to moderate enantiomeric excesses.
Keywords
Phase-transfer catalyst; Michael reactions; Asymmetric reactions; Malonates; Fluoromalonates;
Citations & Related Records

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