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http://dx.doi.org/10.5012/bkcs.2006.27.5.663

Carnosine and Related Compounds Protect against the Hydrogen Peroxide-Mediated Cytochrome c Modification  

Kang, Jung-Hoon (Department of Genetic Engineering, Cheongju University)
Publication Information
Bulletin of the Korean Chemical Society / v.27, no.5, 2006 , pp. 663-666 More about this Journal
Abstract
Carnosine, homocarnosine and anserine might act as anti-oxidants and free radical scavengers in vivo. In the present study, the protective effects of carnosine and related compounds on the $H_2O_2$-mediated cytochrome c modification were studied. Carnosine, homocarnosine and anserine significantly inhibited the oligomerization of cytchrome c induced by $H_2O_2$. All three compounds also inhibited the formation of carbonyl compound and dityrosine during the incubation of cytochrome c with $H_2O_2$. These compounds effectively inhibited the peroxidase activity in the cytchrome c treated with $H_2O_2$. The results suggested that carnosine, homocarnosine, and anserine might protect cytochrome c against $H_2O_2$-mediated oxidative damage through a free radical scavenging.
Keywords
Cytochrome c; OligomerizationFree radical scavenger; Carnosine;
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