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http://dx.doi.org/10.5012/bkcs.2005.26.11.1701

Rapid Synthesis of Arylpiperazine Derivatives for Imaging 5-HT1A Receptor under Microwave Irradiation  

Park, Sang-Hyun (Division of Radioisotope Production and Applications, Center for HANARO Application Research, Korea Atomic Energy Research Institute)
Gwon, Hui-Jeong (Division of Radioisotope Production and Applications, Center for HANARO Application Research, Korea Atomic Energy Research Institute)
Lee, Hyo-Sun (LG Chemical Ltd./Research Park, Science Park)
Park, Kyung-Bae (Division of Radioisotope Production and Applications, Center for HANARO Application Research, Korea Atomic Energy Research Institute)
Publication Information
Bulletin of the Korean Chemical Society / v.26, no.11, 2005 , pp. 1701-1705 More about this Journal
Abstract
We have established an efficient method for the synthesis of the arylpiperazine derivatives in which the acylation of 2-aminopyridine, the coupling reaction of the acyl compound with piperazines, and reduction of the arylpiperazines were performed under a microwave irradiation (300 W) to afford the corresponding target compounds in quantitative yields. In all cases, the reaction times were remarkably reduced when compared with those of the conventional method.
Keywords
Arylpiperazines; Serotonin receptors; Microwave irradiation;
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