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http://dx.doi.org/10.5012/bkcs.2004.25.9.1336

Enantioseparation of Racemic 1,1'Binaphthyl-2,2'diamine by Preparative Liquid Chromatography  

Ryoo, Jae-Jeong (Dept. of Chemistry, Graduate School, Kyungpook National University)
Kwon, Woo-Jeong (Dept. of Chemistry, Graduate School, Kyungpook National University)
Kim, Tae-Hyuk (Dept. of Chemistry, Graduate School, Kyungpook National University)
Lee, Kwang-Pill (Dept. of Chemistry, Graduate School, Kyungpook National University)
Choi, Seong-Ho (Dept. of Chemistry, Hannam University)
Publication Information
Bulletin of the Korean Chemical Society / v.25, no.9, 2004 , pp. 1336-1340 More about this Journal
Abstract
The same kind of chiral stationary phase with a commercialized chiral column was used to make preparative chiral columns and was applied to resolve racemic N-acetyl-1-naphthylethylamide (3) by preparative liquid chromatography. An improved chromatographic condition to resolve racemic 3 on the CSP was examined by changing flow rate and kind of the mobile phase and the sample injection volume. The optimized separation conditions were applied to resolve racemic 1,1'-Binaphthyl-2,2'-diamine(4).
Keywords
Preparative liquid chromatography; Chiral separation; N-Acetyl-1-naphthylethylamide; 1,1'-Binaphthyl-2,2'-diamine; Separation condition;
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