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http://dx.doi.org/10.5012/bkcs.2004.25.8.1225

Metabolic Stability of [18F]Fluoroalkylbiphenyls  

Lee, Kyo-Chul (Korea Institute of Radiological & Medical Sciences)
Lee, Sang-Yoon (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Division of Radiological Sciences, Department of Radiology, Washington University School of Medicine)
Choe, Yearn-Seong (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Chi, Dae-Yoon (Department of Chemistry, Inha University)
Publication Information
Bulletin of the Korean Chemical Society / v.25, no.8, 2004 , pp. 1225-1230 More about this Journal
Abstract
The stability of fluoroalkyl groups as a pendent on the phenyl ring was measured in vitro using rat hepatic microsomes and human serum to predict their in vivo stabilities. We have prepared three [$^{18}F$]fluoroalkyl-biphenyls as the model compounds of fluoroalkyl aromatic compounds to compare the in vitro stabilities. In addition, in vitro stabilities were measured separately using rat hepatic microsomes and human serum at $37^{\circ}C$. Fluoroethylbiphenyl had similar or slightly superior stability to fluoropropylbiphenyl and these two compounds were much more stable than fluoromethylbiphenyl in vitro.
Keywords
Metabolism study; Fluoroalkyl; Fluoroalkylaromatics; Fluorine-18; PET tracer;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 7
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