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http://dx.doi.org/10.5012/bkcs.2004.25.2.249

Oxidative N-Debenzylation of N-Benzyl-N-substituted Benzylamines Catalyzed by Cytochrome P450  

Kim, Sung-Soo (Department of Chemistry and Center for Chemical Dynamics,Inha University)
Lin, Gang (Department of Chemistry and Center for Chemical Dynamics,Inha University)
Yang, Ji-Won (Department of Chemistry and Center for Chemical Dynamics,Inha University)
Publication Information
Bulletin of the Korean Chemical Society / v.25, no.2, 2004 , pp. 249-252 More about this Journal
Abstract
Cytochrome P450 (P450)/$O_2$/NADPH engender electron transfer reaction of N-benzyl-N-substituted benzylamines to yield corresponding radical cation 1 that is simultaneously converted into 2 and 3. Subsequently, expulsion of proton and hydroxylation yielding a-hydroxylamines are followed by formation of benzaldehydes and benzylamines.
Keywords
Oxidations; N-Debenzylations; Horseradish peroxidase; Hydrogen peroxide; Amines;
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