[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2004.25.2.243

A Convenient and Versatile Synthesis of 2' (and 3')-Amino (and azido)-2' (and 3')-deoxyadenosine as Diverse Synthetic Precursors of Cyclic Adenosine Diphosphate Ribose (cADPR)

Kim, Beom-Tae (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University)
Kim, Seung-Ki (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University)
Lee, Seung-Jae (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University)
Hwang, Ki-Jun (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University)

Publication Information

Bulletin of the Korean Chemical Society / v.25, no.2, 2004 , pp. 243-248 More about this Journal

Abstract

As diverse synthetic precursors of cyclic adenosine diphosphate ribose (cADPR), several adenosine derivatives in which azido or amino group is introduced at 2'- or 3'-position of the sugar moiety of adenosine were prepared from readily available adenosine via conventional protocols. These synthetic sequence employs very efficient reactions conditions that proceed at or below ambient temperature with actual yields of >80% for each individual step.

Keywords

Cyclic adenosine diphosphate ribose (cADPR); 2' (and 3')-Amino (and azido)- 2' (and 3')-deoxyadenosine;

Citations & Related Records

Times Cited By Web Of Science : 6 (Related Records In Web of Science)
Times Cited By SCOPUS : 8

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1	/ Bulletin of the Korean Chemical Society
2	/ Bulletin of the Korean Chemical Society
3	/ Nucleosides, Nucleotides and Nucleic Acids
4	/ Bulletin of the Korean Chemical Society
5	/ Bulletin of the Korean Chemical Society
6	/ Organic Letters
7	/ Tetrahedron
8	/ Journal of Organic Chemistry

1	A Synthesis of Sugar-modified S-Adenosyl-L-homocysteine (AdoHcy) Analogues as Inhibitors of AdoHcy Hydrolase / [Kim, Beom-Tae;] / Bulletin of the Korean Chemical Society
2	Straightforward C-8 Alkylation of 2'(or 3')-Azidoadenosine Derivatives by Utilizing Pd(0) Catalyst and Tetraalkyltin / [Kim, Beom-Tae;Moon, Woo-Sung;Lee, Jin-Ho;Hwang, Ki-Jun;] / Bulletin of the Korean Chemical Society
3	The Synthesis of Diverse Adenosine 5'-phosphonate Analogues as Chain Terminators against Hepatitis C Virus (HCV) / [Kim, Bo-Seung;Kim, Beom-Tae;Hwang, Ki-Jun;] / Bulletin of the Korean Chemical Society